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A monoclonal antibody to glucosylceramide inhibits the growth of Fonsecaea pedrosoi and enhances the antifungal action of mouse macrophages.

Abstract:

Fungal glucosylceramides (GlcCer) are conserved lipid components in a large variety of pathogenic and non-pathogenic fungal species, but their biological functions are still unclear. Recent studies demonstrate that GlcCer are immunologically active components inducing the production of antifungal antibodies. In this work, a major GlcCer was purified and characterized from mycelial forms of Fonsecaea pedrosoi, the most frequent causative agent of chromoblastomycosis. As determined by fast atom...

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Publication status:
Published

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Journal:
Microbes and infection / Institut Pasteur
Volume:
6
Issue:
7
Pages:
657-665
Publication date:
2004-06-05
DOI:
EISSN:
1769-714X
ISSN:
1286-4579
URN:
uuid:54629aaf-7892-4c7e-a62b-82e17db909a5
Source identifiers:
230411
Local pid:
pubs:230411

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