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A Phase I trial of the farnesyltransferase inhibitor L-778,123 and radiotherapy for locally advanced lung and head and neck cancer.

Abstract:

PURPOSE: Preclinical data have demonstrated that farnesyltransferaseinhibitors (FTIs) are radiation sensitizers in selected cell lines. The objective of this Phase I trial was to determine the maximally tolerated dose of the FTI L-778,123 in combination with radiotherapy in non-small cell lung cancer (NSCLC) and head and neck cancer (HNC). EXPERIMENTAL DESIGN: L-778,123 was given by continuous i.v. infusion and dose escalated in conjunction with standard radiotherapy. The presence of a ras m...

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Publication status:
Published

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Journal:
Clinical cancer research : an official journal of the American Association for Cancer Research
Volume:
8
Issue:
5
Pages:
1065-1072
Publication date:
2002-05-05
ISSN:
1078-0432
URN:
uuid:545e52b2-8025-4ebb-9010-585b95c2c46c
Source identifiers:
118188
Local pid:
pubs:118188

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