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Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.

Abstract:

Post-translational histone modification has a fundamental role in chromatin biology and is proposed to constitute a 'histone code' in epigenetic regulation. Differential methylation of histone H3 and H4 lysyl residues regulates processes including heterochromatin formation, X-chromosome inactivation, genome imprinting, DNA repair and transcriptional regulation. The discovery of lysyl demethylases using flavin (amine oxidases) or Fe(II) and 2-oxoglutarate as cofactors (2OG oxygenases) has chan...

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Publication status:
Published

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Publisher copy:
10.1038/nature05971

Authors


Kavanagh, KL More by this author
McDonough, MA More by this author
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Journal:
Nature
Volume:
448
Issue:
7149
Pages:
87-91
Publication date:
2007-07-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:545da9d0-2eec-44f0-b3e8-fdd00c4f13cd
Source identifiers:
33899
Local pid:
pubs:33899

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