- Abstract:
-
Post-translational histone modification has a fundamental role in chromatin biology and is proposed to constitute a 'histone code' in epigenetic regulation. Differential methylation of histone H3 and H4 lysyl residues regulates processes including heterochromatin formation, X-chromosome inactivation, genome imprinting, DNA repair and transcriptional regulation. The discovery of lysyl demethylases using flavin (amine oxidases) or Fe(II) and 2-oxoglutarate as cofactors (2OG oxygenases) has chan...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/nature05971
-
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- Journal:
- Nature
- Volume:
- 448
- Issue:
- 7149
- Pages:
- 87-91
- Publication date:
- 2007-07-05
- DOI:
- EISSN:
-
1476-4687
- ISSN:
-
0028-0836
- URN:
-
uuid:545da9d0-2eec-44f0-b3e8-fdd00c4f13cd
- Source identifiers:
-
33899
- Local pid:
- pubs:33899
- Language:
- English
- Keywords:
- Copyright date:
- 2007
Journal article
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.
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