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Spontaneous class switching and B cell hyperactivity increase autoimmunity against intracellular self antigen in Lyn-deficient mice.

Abstract:

IgG autoantibodies cause pathology due to their ability to bind self antigens. However, the extent to which the initial B cell activation and isotype switching is antigen-driven is unclear and it has been widely proposed that intrinsic B cell hyperactivity may be a contributing factor. To explore this issue we generated mice with B cell hyperactivity secondary to deficiency in the src kinase Lyn that also expressed a gene-targeted anti-hen egg lysozyme Ig construct (VDJkappa) capable of class...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200636462

Authors


Bouriez-Jones, T More by this author
Crockford, T More by this author
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Journal:
European journal of immunology
Volume:
36
Issue:
11
Pages:
2920-2927
Publication date:
2006-11-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:544b03b0-b066-42ed-abaf-ef41e0443449
Source identifiers:
23702
Local pid:
pubs:23702

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