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A clinicopathological correlation of the expression of the angiopoietin-Tie-2 receptor pathway in the brain of adults with Plasmodium falciparum malaria.

Abstract:

Background: Plasma angiopoietin (Ang)-2 is associated with disease severity and mortality in adults and children with falciparum malaria. However the mechanism of action of the angiopoietins in fatal malaria is unclear. This study aimed to determine whether the expression of Ang-1 and Ang-2 and their receptor Tie-2 in cerebral endothelial or parenchymal cells was specific to cerebral malaria (CM), correlated with coma or other severe clinical features, and whether plasma and CSF levels of ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/1475-2875-12-50

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Role:
Author
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John Fell Fund More from this funder
Thrasher Research Fund More from this funder
Publisher:
BioMed Central Ltd. Publisher's website
Journal:
Malar J Journal website
Volume:
12
Issue:
1
Pages:
Article: 50
Publication date:
2013-01-01
DOI:
EISSN:
1475-2875
ISSN:
1475-2875
URN:
uuid:544a7e89-7e76-462b-8096-4fdf11e799c8
Source identifiers:
384098
Local pid:
pubs:384098

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