Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.

Journal article

Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 × 10(-8) to P = 2.3 × 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21....

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Authors: Wain, L; Verwoert, G; O'Reilly, P; Shi, G; Johnson, T

• Publication status: Published
• Journal: Nature genetics
• Volume: 43
• Issue: 10
• Pages: 1005-1011
• Publication date: 2011-10-01
• DOI: 10.1038/ng.922
• EISSN: 1546-1718
• ISSN: 1061-4036
• Language: English
• Keywords: Genome-Wide Association Study; Linkage Disequilibrium; Blood Pressure; Cardiogenics consortium; Follow-Up Studies; KidneyGen consortium; CardioGram; Arteries; AortaGen Consortium; LifeLines Cohort Study; Polymorphism, Single Nucleotide; CKDGen consortium; Genetic Loci; Case-Control Studies; Hypertension; Humans; CHARGE Consortium Heart Failure Working Group; EchoGen consortium