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The influence of environment: simulations of the influenza BM2 proton channel

Abstract:

The influenza BM2 proton channel is a small, tetrameric α-helical membrane protein, which is vital in multiple stages of the life cycle of the virus. The transmembrane (TM) domain is responsible for modulating pH to facilitate release of viral genetic material whilst the cytoplasmic domain is purported to play a role in virus budding via interactions with another protein, BM1.

Coarse-grained molecular dynamics (CGMD) simulations have been employed in several studies of α-helical mem... Expand abstract

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Institution:
University of Oxford
Research group:
Sansom Group, SBCB Unit
Oxford college:
Keble College
Department:
Medical Sciences Division - Biochemistry
Role:
Author

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Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral

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