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Protective effect of the specific endothelin-1 antagonist BQ610 on mechanical function and energy metabolism during ischemia/reperfusion injury in isolated perfused rat hearts.

Abstract:

Endothelin-1 (ET-1) has been suggested to be involved in the pathophysiology of ischemia/reperfusion injury, but direct proof for this is still sparse. We tested whether protection of high-energy phosphate metabolism contributes to the beneficial effects of ETA receptor antagonists during ischemia/reperfusion. In isolated, buffer-perfused rat hearts, isovolumic function was measured by a left ventricular (LV) balloon, and 31P nuclear magnetic resonance spectra were continuously recorded. Two ...

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Journal:
Journal of cardiovascular pharmacology
Volume:
27
Issue:
4
Pages:
487-494
Publication date:
1996-04-05
DOI:
EISSN:
1533-4023
ISSN:
0160-2446
URN:
uuid:542654fc-72c3-4a33-9b97-ff724094d76b
Source identifiers:
441402
Local pid:
pubs:441402

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