Immune response (Ir) genes expressed at macrophage-B lymphocyte interactions.
The mode of action of the MHC-linked Ir genes is not known. Many hypotheses have been proposed both for their cellular site of action, that is, on T cells, B cells or macrophages, and for their mechanism of action. Recently, the authors discussed the possibility that as macrophages are required for T and B lymphocyte activities, the available data were compatible with Ir genes expressed at the macrophage-lymphocyte interactions, with either T cells or B cells. Results implying the involvement...Expand abstract
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