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Large-scale bioreactor expansion of tumor-infiltrating lymphocytes.

Abstract:

BACKGROUND: The aim of this study was to evaluate an improved technique for expansion of tumor-infiltrating lymphocytes (TILs) based on the WAVE Bioreactor system with perfusion and tube-welding techniques. Our hypothesis was that the bioreactor would allow for optimized provision of nutrients and removal of spent media while minimizing culture volumes. These refinements might lead to a better quality of expanded cells with lower amounts of exhausted cells compared to static expansions in cu...

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Publisher copy:
10.1016/j.jim.2010.11.007

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Role:
Author
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Journal:
Journal of immunological methods
Volume:
364
Issue:
1-2
Pages:
94-100
Publication date:
2011-02-05
DOI:
EISSN:
1872-7905
ISSN:
0022-1759
URN:
uuid:541e37f2-452d-4e50-80b8-e7b6a2e004ea
Source identifiers:
270769
Local pid:
pubs:270769

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