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Canonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis.

Abstract:

Nuclear factor kappa B (NF-kappa B) activation has been observed in human atherosclerotic plaques and is enhanced in unstable coronary plaques, but whether such activation has a protective or pathophysiological role remains to be determined. We addressed this question by developing a short-term culture system of cells isolated from human atherosclerotic tissue, allowing efficient gene transfer to directly investigate signaling pathways in human atherosclerosis. We found that NF-kappa B is act...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0401060101

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, BHF Centre of Research Excellence
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
101
Issue:
15
Pages:
5634-5639
Publication date:
2004-04-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:5416c7b0-1518-401c-bca4-bf59bf9555de
Source identifiers:
224586
Local pid:
pubs:224586

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