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Transient intercellular adhesion: the importance of weak protein-protein interactions.

Abstract:
Intercellular adhesion is a complex phenomenon central to the development, structure and functioning of all multicellular organisms. Adhesion is mediated by distinct families of cell-adhesion molecules (CAMs), and recent studies have identified key characteristics of CAMs that influence their function. Affinity and kinetic analyses using a novel technique based on surface plasmon resonance have shown that CAM interactions that mediate transient cell adhesion may have surprisingly low affinities and extremely fast dissociation rate constants.

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Barclay, AN More by this author
Journal:
Trends in biochemical sciences
Volume:
19
Issue:
9
Pages:
354-358
Publication date:
1994-09-05
DOI:
ISSN:
0968-0004
URN:
uuid:54068843-77f2-44d7-b569-829965306404
Source identifiers:
676
Local pid:
pubs:676

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