- Abstract:
-
Germ-line mutations in breast cancer 1, early onset (BRCA1) result in predisposition to breast and ovarian cancer. BRCA1-mutated tumors show genomic instability, mainly as a consequence of impaired recombinatorial DNA repair. Here we identify p53-binding protein 1 (53BP1) as an essential factor for sustaining the growth arrest induced by Brca1 deletion. Depletion of 53BP1 abrogates the ATM-dependent checkpoint response and G2 cell-cycle arrest triggered by the accumulation of DNA breaks in Br...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/nsmb.1831
-
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- Journal:
- Nature structural and molecular biology
- Volume:
- 17
- Issue:
- 6
- Pages:
- 688-695
- Publication date:
- 2010-06-05
- DOI:
- EISSN:
-
1545-9985
- ISSN:
-
1545-9993
- URN:
-
uuid:54020cd6-9bbb-4d8f-adc0-99d6940fea13
- Source identifiers:
-
131253
- Local pid:
- pubs:131253
- Language:
- English
- Keywords:
- Copyright date:
- 2010
Journal article
53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers.
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