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Journal article

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers.

Abstract:

Germ-line mutations in breast cancer 1, early onset (BRCA1) result in predisposition to breast and ovarian cancer. BRCA1-mutated tumors show genomic instability, mainly as a consequence of impaired recombinatorial DNA repair. Here we identify p53-binding protein 1 (53BP1) as an essential factor for sustaining the growth arrest induced by Brca1 deletion. Depletion of 53BP1 abrogates the ATM-dependent checkpoint response and G2 cell-cycle arrest triggered by the accumulation of DNA breaks in Br...

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Publication status:
Published

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Publisher copy:
10.1038/nsmb.1831

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Journal:
Nature structural and molecular biology
Volume:
17
Issue:
6
Pages:
688-695
Publication date:
2010-06-05
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
URN:
uuid:54020cd6-9bbb-4d8f-adc0-99d6940fea13
Source identifiers:
131253
Local pid:
pubs:131253

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