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The effect of moderate acute psychological stress on working memory-related neural activity is modulated by a genetic variation in catecholaminergic function in humans

Abstract:

Acute stress has an important impact on higher-order cognitive functions supported by the prefrontal cortex (PFC) such as working memory (WM). In rodents, such effects are mediated by stress-induced alterations in catecholaminergic signaling, but human data in support of this notion is lacking. A common variation in the gene encoding Catechol-O42 methyltransferase (COMT) is known to affect basal catecholaminergic availability and PFC functions. Here, we investigated whether this genetic varia...

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Publisher copy:
10.3389/fnint.2012.00016

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
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Publisher:
Frontiers Research Foundation
Journal:
Frontiers in Integrative Neuroscience
Issue:
APRIL
Pages:
1-29
Publication date:
2012-01-01
DOI:
ISSN:
1662-5145
URN:
uuid:54017566-ef82-4e16-acbe-0140038d316d
Source identifiers:
348991
Local pid:
pubs:348991

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