Journal article

Computational pharmacokinetics of solute penetration into human intervertebral discs-Effects of endplate permeability, solute molecular weight and disc size

Abstract:: A finite element model is developed to predict the penetration time-history of three different solutes into the human lumbar disc following intravenous injection. Antibiotics are routinely administered intravenously in spinal surgery to prevent disc infection. Successful prophylaxis requires antibiotics to reach adequate inhibitory levels. Here, the transient diffusion of cephazolin is investigated over 10. h post-injection in a human disc model subject to reported concentrations in the blood...
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APA Style

Motaghinasab, S., Shirazi-Adl, A., Urban, J., & Parnianpour, M. (2012). Computational pharmacokinetics of solute penetration into human intervertebral discs-Effects of endplate permeability, solute molecular weight and disc size. Journal of Biomechanics, 45(13), 2195–2202.

MLA Style

Motaghinasab, S., et al. “Computational Pharmacokinetics of Solute Penetration into Human Intervertebral Discs-Effects of Endplate Permeability, Solute Molecular Weight and Disc Size.” Journal of Biomechanics, vol. 45, no. 13, 2012, pp. 2195–202.

Chicago Style

Motaghinasab, S, A Shirazi-Adl, J Urban, and M Parnianpour. 2012. “Computational Pharmacokinetics of Solute Penetration into Human Intervertebral Discs-Effects of Endplate Permeability, Solute Molecular Weight and Disc Size.” Journal of Biomechanics 45 (13): 2195–2202.
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Publisher copy:: 10.1016/j.jbiomech.2012.06.033

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+ Motaghinasab, S More by this author

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+ Shirazi-Adl, A More by this author

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+ Urban, J More by this author

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+ Parnianpour, M More by this author

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Bibliographic Details

Journal:: Journal of Biomechanics More from this journal
Volume:: 45
Issue:: 13
Pages:: 2195-2202
Publication date:: 2012-08-31
DOI:: 10.1016/j.jbiomech.2012.06.033
EISSN:: 1873-2380
ISSN:: 0021-9290

Item Description

Language:: English
Keywords:: Cephazolin

Diffusion

Molecular weight

Intervertebral disc

Endplate

Finite element

Disc size
Pubs id:: pubs:351136
UUID:: uuid:53fd0614-c602-4035-97d7-4e43f90e8b84
Local pid:: pubs:351136
Source identifiers:: 351136
Deposit date:: 2013-11-16

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Copyright date:: 2012

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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