- Abstract:
-
Purpose:
Ionizing radiation, particular high-linear energy transfer (LET) radiation, can induce complex DNA damage (CDD) wherein 2 or more DNA lesions are induced in close proximity, which contributes significantly to the cell killing effects. However, knowledge of the enzymes and mechanisms involved in coordinating the recognition and processing of CDD in cellular DNA are currently lacking.
Methods and Materials:
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A small interfering ... - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 2.2mb)
-
- Publisher copy:
- 10.1016/j.ijrobp.2019.02.053
-
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- Publisher:
- Elsevier Publisher's website
- Journal:
- International Journal of Radiation Oncology - Biology - Physics Journal website
- Volume:
- 104
- Issue:
- 3
- Pages:
- 656-665
- Publication date:
- 2019-03-07
- Acceptance date:
- 2019-02-26
- DOI:
- EISSN:
-
1879-355X
- ISSN:
-
0360-3016
- Pubs id:
-
pubs:983975
- URN:
-
uri:53fb6930-93c1-4ce0-874b-c7310e3220fe
- UUID:
-
uuid:53fb6930-93c1-4ce0-874b-c7310e3220fe
- Local pid:
- pubs:983975
- Language:
- English
- Copyright holder:
- Carter et al.
- Copyright date:
- 2019
- Notes:
- © The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Journal article
Characterisation of deubiquitylating enzymes in the cellular response to high-LET ionizing radiation and complex DNA damage
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