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Journal article

Characterisation of deubiquitylating enzymes in the cellular response to high-LET ionizing radiation and complex DNA damage

Abstract:

Purpose:
Ionizing radiation, particular high-linear energy transfer (LET) radiation, can induce complex DNA damage (CDD) wherein 2 or more DNA lesions are induced in close proximity, which contributes significantly to the cell killing effects. However, knowledge of the enzymes and mechanisms involved in coordinating the recognition and processing of CDD in cellular DNA are currently lacking.


Methods and Materials:
A small interfering ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/j.ijrobp.2019.02.053

Authors


Carter, RJ More by this author
Nickson, CM More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Subgroup:
CRUK/MRC Ox Inst Radiation Oncology
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Subgroup:
CRUK/MRC Ox Inst Radiation Oncology
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Subgroup:
CRUK/MRC Ox Inst Radiation Oncology
Oxford college:
Wolfson
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Publisher:
Elsevier Publisher's website
Journal:
International Journal of Radiation Oncology - Biology - Physics Journal website
Volume:
104
Issue:
3
Pages:
656-665
Publication date:
2019-03-07
Acceptance date:
2019-02-26
DOI:
EISSN:
1879-355X
ISSN:
0360-3016
Pubs id:
pubs:983975
URN:
uri:53fb6930-93c1-4ce0-874b-c7310e3220fe
UUID:
uuid:53fb6930-93c1-4ce0-874b-c7310e3220fe
Local pid:
pubs:983975
Language:
English

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