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Direct measurements of increased free cytoplasmic Ca2+ in mouse pancreatic beta-cells following stimulation by hypoglycemic sulfonylureas.

Abstract:

The effects of the hypoglycemic sulfonylureas tolbutamide and glibenclamide on free cytoplasmic Ca2+, [Ca2+]i, were compared with that of a depolarizing concentration of K+ in dispersed and cultured pancreatic beta-cells from ob/ob mice. [Ca2+]i was measured with the fluorescent Ca2+-indicator quin2. The basal level corresponded to 150 nM and increased to 600 nM after exposure to 30.9 mM K+. The corresponding levels after stimulation with 1 microM glibenclamide and 100 microM tolbutamide were...

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Publication status:
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Authors


Abrahamsson, H More by this author
Berggren, PO More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Journal:
FEBS letters
Volume:
190
Issue:
1
Pages:
21-24
Publication date:
1985-10-05
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
URN:
uuid:53f8494a-5247-407a-a85f-a75d85632f97
Source identifiers:
15087
Local pid:
pubs:15087

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