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Direct measurements of increased free cytoplasmic Ca2+ in mouse pancreatic beta-cells following stimulation by hypoglycemic sulfonylureas.

Abstract:

The effects of the hypoglycemic sulfonylureas tolbutamide and glibenclamide on free cytoplasmic Ca2+, [Ca2+]i, were compared with that of a depolarizing concentration of K+ in dispersed and cultured pancreatic beta-cells from ob/ob mice. [Ca2+]i was measured with the fluorescent Ca2+-indicator quin2. The basal level corresponded to 150 nM and increased to 600 nM after exposure to 30.9 mM K+. The corresponding levels after stimulation with 1 microM glibenclamide and 100 microM tolbutamide were...

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
Journal:
FEBS letters
Volume:
190
Issue:
1
Pages:
21-24
Publication date:
1985-10-01
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
Source identifiers:
15087
Language:
English
Keywords:
Pubs id:
pubs:15087
UUID:
uuid:53f8494a-5247-407a-a85f-a75d85632f97
Local pid:
pubs:15087
Deposit date:
2012-12-19

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