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Journal article

Peptide splicing by the proteasome.

Abstract:

The proteasome is the major protease responsible for the production of antigenic peptides recognized by CD8+ cytolytic T cells (CTL). These peptides, generally 8-to-10 amino acid-long, are presented at the cell surface by major histocompatibility complex (MHC) class I molecules. Although for years, these peptides were believed to solely derive from linear fragments of proteins, this concept was challenged several years ago by the isolation of anti-tumor CTL that recognized spliced peptides, i...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1074/jbc.r117.807560

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Ludwig Institute
Role:
Author
ORCID:
0000-0002-4995-3270
Belgian National Fund for Scientific Research More from this funder
Publisher:
American Society for Biochemistry and Molecular Biology Publisher's website
Journal:
Journal of Biological Chemistry Journal website
Volume:
292
Issue:
51
Pages:
21170–21179
Publication date:
2017-11-06
Acceptance date:
2017-11-06
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Pubs id:
pubs:809045
URN:
uri:53f4335d-54b5-4c12-8d05-cb2abf43e023
UUID:
uuid:53f4335d-54b5-4c12-8d05-cb2abf43e023
Local pid:
pubs:809045

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