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Dissociation of reward and effort sensitivity in methcathinone-induced Parkinsonism

Abstract:

Methcathinone-induced Parkinsonism is a recently described extrapyramidal syndrome characterized by globus pallidus and substantia nigra lesions, which provides a unique model of basal ganglia dysfunction. We assessed motivated behaviour in this condition using a novel cost-benefit decision-making task, in which participants decided whether it was worth investing effort for reward. Patients showed a dissociation between reward and effort sensitivity, such that pallidonigral complex dysfunctio...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1111/jnp.12122

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Department:
Oxford, MSD, Experimental Psychology
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Author
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Department:
Oxford, MSD, Experimental Psychology
Role:
Author
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Department:
Oxford, MSD, Experimental Psychology
Role:
Author
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Publisher:
Wiley Publisher's website
Journal:
Journal of Neuropsychology Journal website
Volume:
12
Issue:
2
Pages:
291-297
Publication date:
2017-04-05
Acceptance date:
2017-02-11
DOI:
EISSN:
1748-6653
ISSN:
1748-6645
Pubs id:
pubs:695550
URN:
uri:53effe08-0e24-4122-809c-5d25b076cc96
UUID:
uuid:53effe08-0e24-4122-809c-5d25b076cc96
Local pid:
pubs:695550

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