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Journal article

Evolutionary reversals of antibiotic resistance in experimental populations of Pseudomonas aeruginosa.

Abstract:

Antibiotic resistance mutations are accompanied by a fitness cost, and two mechanisms allow bacteria to adapt to this cost once antibiotic use is halted. First, it is possible for resistance to revert; second, it is possible for bacteria to adapt to the cost of resistance by compensatory mutations. Unfortunately, reversion to antibiotic sensitivity is rare, but the underlying factors that prevent reversion remain obscure. Here, we directly study the evolutionary dynamics of reversion by exper...

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Publication status:
Published

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Publisher copy:
10.1111/evo.12158

Authors


Gifford, DR More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Journal:
Evolution; international journal of organic evolution
Volume:
67
Issue:
10
Pages:
2973-2981
Publication date:
2013-10-05
DOI:
EISSN:
1558-5646
ISSN:
0014-3820
URN:
uuid:53ed597e-9c84-494e-aaa3-9814cad1b431
Source identifiers:
408099
Local pid:
pubs:408099

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