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Imbalance of a serotonergic system in frontotemporal dementia: implication for pharmacotherapy.

Abstract:

RATIONALE: Information is sparse on neurotransmitter deficiencies in frontotemporal dementia (FTD), in particular with reference to distinct histological subgroups and Alzheimer's disease (AD). OBJECTIVES: To evaluate in FTD with the major histologies, and compare with AD and controls, neurotransmission indices, as these may help in developing treatment. MATERIALS AND METHODS: Post-mortem grey matter from Brodmann Area 21, 9 and 7 of 51 brains was assayed for ten neurochemical parameters inde...

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Publication status:
Published

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Publisher copy:
10.1007/s00213-007-0992-8

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
Role:
Author
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Journal:
Psychopharmacology
Volume:
196
Issue:
4
Pages:
603-610
Publication date:
2008-03-05
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
URN:
uuid:53eb5fe0-4899-43b8-9f18-d663b789c629
Source identifiers:
243231
Local pid:
pubs:243231

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