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Ion channels, electrical activity and insulin secretion.

Abstract:

The insulin-secreting pancreatic beta cell is electrically excitable and changes in the membrane potential play an important role in coupling the metabolism of glucose (and other nutrient secretagogues) to the discharge of the insulin-containing granule. The application of the patch-clamp technique, which permits the recordings of the minute currents associated with the opening of individual ion channels, to pancreatic islet cells has revolutionized our understanding of the beta cell electrop...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Bokvist, K More by this author
Ammälä, C More by this author
Eliasson, L More by this author
Renström, E More by this author
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Volume:
20
Issue:
2
Pages:
138-145
Publication date:
1994-03-05
ISSN:
0338-1684
URN:
uuid:53e2df24-74f7-4899-9e87-5872e8e7e9c5
Source identifiers:
7099
Local pid:
pubs:7099

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