Cholinergic interneurons (ChIs) of the striatum pause their firing in response to salient stimuli and conditioned stimuli after learning. Several different mechanisms for pause generation have been proposed but a unifying basis has not previously emerged. Here, using in vivo and ex vivo recordings in rat and mouse brain and a computational model, we show that ChI pauses are driven by withdrawal of excitatory inputs to striatum and result from a delayed-rectifier potassium cu...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
- Publisher's version
- Elsevier (Cell Press) Publisher's website
- Neuron Journal website
- Publication date:
- Acceptance date:
- Pubs id:
- Local pid:
- Copyright holder:
- Zhang et al.
- Copyright date:
© 2018 The Author(s). Published by Elsevier Inc.
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Pauses in cholinergic interneuron activity are driven by excitatory input and delayed rectification, with dopamine modulation
If you are the owner of this record, you can report an update to it here: Report update to this record