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Pauses in cholinergic interneuron activity are driven by excitatory input and delayed rectification, with dopamine modulation

Abstract:

Cholinergic interneurons (ChIs) of the striatum pause their firing in response to salient stimuli and conditioned stimuli after learning. Several different mechanisms for pause generation have been proposed but a unifying basis has not previously emerged. Here, using in vivo and ex vivo recordings in rat and mouse brain and a computational model, we show that ChI pauses are driven by withdrawal of excitatory inputs to striatum and result from a delayed-rectifier potassium cu...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.neuron.2018.04.027

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Reynolds, JNJ More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Oxford college:
Christ Church
Publisher:
Elsevier (Cell Press) Publisher's website
Journal:
Neuron Journal website
Volume:
98
Issue:
5
Pages:
918-925.e3
Publication date:
2018-05-10
Acceptance date:
2018-04-19
DOI:
EISSN:
1097-4199
ISSN:
0896-6273
Pubs id:
pubs:842349
URN:
uri:53e28125-2e0b-46cb-ab12-3f86d9c3607f
UUID:
uuid:53e28125-2e0b-46cb-ab12-3f86d9c3607f
Local pid:
pubs:842349

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