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Whole-brain comparison of rodent and human brains using spatial transcriptomics

Abstract:

The ever-increasing use of mouse models in preclinical neuroscience research calls for an improvement in the methods used to translate findings between mouse and human brains. Previously, we showed that the brains of primates can be compared in a direct quantitative manner using a common reference space built from white matter tractography data (Mars et al., 2018b). Here, we extend the common space approach to evaluate the similarity of mouse and human brain regions using openly accessible br...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/elife.79418

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Role:
Author
ORCID:
0000-0002-0008-7471
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Role:
Author
ORCID:
0000-0001-7083-1932
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Role:
Author
ORCID:
0000-0001-8689-046X
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Role:
Author
ORCID:
0000-0002-5622-1190
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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
ORCID:
0000-0001-6302-8631
Publisher:
eLife Sciences Publications
Journal:
eLife More from this journal
Volume:
11
Article number:
e79418
Publication date:
2022-11-07
Acceptance date:
2022-11-04
DOI:
EISSN:
2050-084X
Language:
English
Keywords:
Pubs id:
1300862
Local pid:
pubs:1300862
Deposit date:
2022-11-09

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