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Thesis

Molecular determinants of chromatin accessibility at CpG islands in mouse embryonic stem cells

Abstract:

In eukaryotic cells, transcription factors and polymerases must access DNA in the context of nucleosomes and chromatin. The accessibility of DNA sequences to such trans-acting factors is an important feature of gene regulatory elements, including promoters. In vertebrates, the majority of gene promoters coincide with CpG islands (CGIs), which remain free from DNA methylation and exhibit elevated CpG densities. This hypomethylated and CpG-rich state at CGI promoters is associated n...

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Hamish King More by this author

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Role:
Supervisor
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Funding agency for:
Hamish King
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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