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Journal article

Chemosensitization of Plasmodium falciparum by probenecid in vitro.

Abstract:

Resistance to drugs can result from changes in drug transport, and this resistance can sometimes be overcome by a second drug that modifies the transport mechanisms of the cell. This strategy has been exploited to partly reverse resistance to chloroquine in Plasmodium falciparum. Studies with human tumor cells have shown that probenecid can reverse resistance to the antifolate methotrexate, but the potential for reversal of antifolate resistance has not been studied in P. falciparum. In the p...

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Publication status:
Published

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Authors


Kokwaro, G More by this author
Winstanley, P More by this author
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Journal:
Antimicrobial agents and chemotherapy
Volume:
47
Issue:
7
Pages:
2108-2112
Publication date:
2003-07-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:53cc80ff-9b99-4580-bec5-6b32afd20a82
Source identifiers:
38631
Local pid:
pubs:38631

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