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A mathematical model for germinal centre kinetics and affinity maturation

Abstract:

We present a mathematical model which reproduces experimental data on the germinal centre (GC) kinetics of the primed primary immune response and on affinity maturation observed during the reaction. We show that antigen masking by antibodies which are produced by emerging plasma cells can drive affinity maturation and provide a feedback mechanism by which the reaction is stable against variations in the initial antigen amount over several orders of magnitude. This provides a possible answer t...

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Publication date:
2002-01-01
URN:
uuid:53a73b8d-55a9-44ff-ac58-888d4c5a74ad
Local pid:
oai:eprints.maths.ox.ac.uk:385

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