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Journal article

Geographical distribution and disease associations of the CD45 exon 6 138G variant.

Abstract:

CD45 is crucial for normal lymphocyte signalling, and altered CD45 expression has major effects on immune function. Both mice and humans lacking CD45 expression are severely immunodeficient, and single-nucleotide polymorphisms in the CD45 gene that cause altered splicing have been associated with autoimmune and infectious diseases. Recently, we identified an exon 6 A138G polymorphism resulting in an increased proportion of activated CD45RO T cells and altered immune function. Here we report a...

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Publication status:
Published

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Publisher copy:
10.1007/s00251-006-0099-0

Authors


Hennig, BJ More by this author
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Journal:
Immunogenetics
Volume:
58
Issue:
2-3
Pages:
235-239
Publication date:
2006-04-05
DOI:
EISSN:
1432-1211
ISSN:
0093-7711
URN:
uuid:53a7217c-c2c7-4644-8c58-fa9257635700
Source identifiers:
33419
Local pid:
pubs:33419

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