Journal article
The stability of triplex DNA is affected by the stability of the underlying duplex.
- Abstract:
-
We have studied the formation of DNA triple helices in different sequence contexts and show that, for the most stable triplexes, their apparent stability is affected by the stability of the underlying duplex. For a 14-mer parallel triplex-forming oligonucleotide (generating C(+).GC and T.AT triplets) at pH 5.0 the T(m) is more than 10 degrees C lower with an intermolecular 14-mer duplex target, than it is with an intramolecular duplex, or one which is flanked by 6 GC base pairs at either end....
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.bpc.2009.09.007
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Bibliographic Details
- Journal:
- Biophysical chemistry
- Volume:
- 145
- Issue:
- 2-3
- Pages:
- 105-110
- Publication date:
- 2009-12-01
- DOI:
- EISSN:
-
1873-4200
- ISSN:
-
0301-4622
- Source identifiers:
-
400006
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:400006
- UUID:
-
uuid:53a4b368-6b80-4219-abe6-64b7315057e3
- Local pid:
- pubs:400006
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2009
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