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Journal article

The stability of triplex DNA is affected by the stability of the underlying duplex.

Abstract:

We have studied the formation of DNA triple helices in different sequence contexts and show that, for the most stable triplexes, their apparent stability is affected by the stability of the underlying duplex. For a 14-mer parallel triplex-forming oligonucleotide (generating C(+).GC and T.AT triplets) at pH 5.0 the T(m) is more than 10 degrees C lower with an intermolecular 14-mer duplex target, than it is with an intramolecular duplex, or one which is flanked by 6 GC base pairs at either end....

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Publication status:
Published

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Publisher copy:
10.1016/j.bpc.2009.09.007

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
Biophysical chemistry
Volume:
145
Issue:
2-3
Pages:
105-110
Publication date:
2009-12-05
DOI:
EISSN:
1873-4200
ISSN:
0301-4622
URN:
uuid:53a4b368-6b80-4219-abe6-64b7315057e3
Source identifiers:
400006
Local pid:
pubs:400006

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