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Inhibition of Na+/K(+)-ATPase may be one mechanism contributing to potassium efflux and cell shrinkage in CD95-induced apoptosis.

Abstract:

To investigate the involvement of K+ efflux in apoptotic cell shrinkage, we monitored efflux of the K+ congener, 86Rb+, and cell volume during CD95-mediated apoptosis in Jurkat cells. An anti-CD95 antibody caused apoptosis associated with intracellular GSH depletion, a significant increase in 86Rb+ efflux, and a decrease in cell volume compared with control cells. Preincubating Jurkat cells with Val-Ala-Asp-chloromethylketone (VAD-cmk), an inhibitor of caspase proteases, prevented the observe...

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Publication status:
Published

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Publisher copy:
10.1023/a:1009684713784

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, PHC-Seniors
van den Dobbelsteen, DJ More by this author
Slater, AF More by this author
Journal:
Apoptosis : an international journal on programmed cell death
Volume:
5
Issue:
2
Pages:
153-163
Publication date:
2000-04-05
DOI:
EISSN:
1573-675X
ISSN:
1360-8185
URN:
uuid:5399c5f1-0d87-4849-8a2b-8ee1b2cbaa44
Source identifiers:
117082
Local pid:
pubs:117082

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