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PGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2.

Abstract:

Prostaglandin H(1) (PGH(1)) is the cyclo-oxygenase metabolite of dihomo-γ-linolenic acid (DGLA) and the precursor for the 1-series of prostaglandins which are often viewed as "anti-inflammatory". Herein we present evidence that PGH(1) is a potent activator of the pro-inflammatory PGD(2) receptor CRTH2, an attractive therapeutic target to treat allergic diseases such as asthma and atopic dermatitis. Non-invasive, real time dynamic mass redistribution analysis of living human CRTH2 transfectant...

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Publisher copy:
10.1371/journal.pone.0033329

Authors


Schröder, R More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Martini, L More by this author
Kampitsch, N More by this author
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Journal:
PloS one
Volume:
7
Issue:
3
Pages:
e33329
Publication date:
2012
DOI:
EISSN:
1932-6203
URN:
uuid:53896895-2431-4217-abd9-ae8c83727dde
Source identifiers:
321524
Local pid:
pubs:321524

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