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Journal article

Cited1 is required in trophoblasts for placental development and for embryo growth and survival

Abstract:

Cited1 is a transcriptional cofactor that interacts with Smad4, estrogen receptors α and β, TFAP2, and CBP/p300. It is expressed in a restricted manner in the embryo as well as in extraembryonic tissues during embryonic development. In this study we report the engineering of a loss-of-function Cited1 mutation in the mouse. Cited1 null mutants show growth restriction at 18.5 days postcoitum, and most of them die shortly after birth. Half the heterozygous females, i.e., those that carry a pater...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Publisher:
American Society for Microbiology Publisher's website
Journal:
Molecular and Cellular Biology Journal website
Volume:
24
Issue:
1
Pages:
228-244
Publication date:
2004-01-01
DOI:
ISSN:
0270-7306
URN:
uuid:537a38b3-4c83-4126-87ab-a86fbef07db0
Source identifiers:
573471
Local pid:
pubs:573471

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