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Thesis

Novel therapeutic strategies for targeting EGFR mutated non-small cell lung cancer

Abstract:

Background: NSCLC patients with EGFR M+ tumours have marked clinical responses to EGFR-TKIs. Most patients experience tumour regrowth, as drug resistance emerges through on-target secondary EGFR-mutations or other activating mutations that reactivate the downstream signalling. However, a significant number of patients become drug resistant through unknown mechanisms of resistance and these currently represent an area of high unmet clinical need. In this work, we aim to understand bio...

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Division:
MSD
Department:
Oncology
Role:
Author

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Role:
Supervisor
Medical Research Council More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:53788e9e-20f1-44da-bb47-7da5884f3093
Deposit date:
2018-06-20

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