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Thesis

Novel therapeutic strategies for targeting EGFR mutated non-small cell lung cancer

Abstract:

Background: NSCLC patients with EGFR M+ tumours have marked clinical responses to EGFR-TKIs. Most patients experience tumour regrowth, as drug resistance emerges through on-target secondary EGFR-mutations or other activating mutations that reactivate the downstream signalling. However, a significant number of patients become drug resistant through unknown mechanisms of resistance and these currently represent an area of high unmet clinical need. In this work, we aim to understand bio...

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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