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A brain-based pain facilitation mechanism contributes to painful diabetic polyneuropathy

Abstract:

The descending pain modulatory system represents one of the oldest and most fundamentally important neurophysiological mechanisms relevant to pain. Extensive work in animals and humans has shown how a functional imbalance between the facilitatory and inhibitory components is linked to exacerbation and maintenance of persistent pain states. Forward translation of these findings into clinical populations is needed to verify the relevance of this imbalance. Diabetic polyneuropathy is one of the ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/brain/awx337

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
More by this author
Institution:
University of Oxford
Department:
Clinical Neurosciences
More by this author
Institution:
University of Oxford
Department:
Clinical Neurosciences
More by this author
Institution:
University of Oxford
Department:
Clinical Neurosciences
More by this author
Institution:
University of Oxford
Department:
Clinical Neurosciences
Medical Research Council More from this funder
Wellcome Trust More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Brain Journal website
Volume:
141
Issue:
2
Pages:
357-364
Publication date:
2018-01-15
Acceptance date:
2017-10-19
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Pmid:
29346515
Pubs id:
pubs:821023
UUID:
uuid:53772324-8f21-4c53-9ef6-be95e975999c
Source identifiers:
821023
Local pid:
pubs:821023

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