Journal article icon

Journal article

From blood to lung tissue: effect of cigarette smoke on DNA methylation and lung function

Abstract:

Background

Genetic and environmental factors play a role in the development of COPD. The epigenome, and more specifically DNA methylation, is recognized as important link between these factors. We postulate that DNA methylation is one of the routes by which cigarette smoke influences the development of COPD. In this study, we aim to identify CpG-sites that are associated with cigarette smoke exposure and lung function levels in whole blood and validate these CpG-sites in lung tis...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1186/s12931-018-0904-y

Authors


More by this author
ORCID:
0000-0001-7210-8174
More by this author
ORCID:
0000-0002-0361-357X
Nedeljkovic, I More by this author
Verkaik-Schakel, RN More by this author
Kooistra, W More by this author
Expand authors...
Publisher:
BioMed Central Publisher's website
Journal:
Respiratory Research Journal website
Volume:
19
Issue:
1
Pages:
212
Publication date:
2018-11-03
Acceptance date:
2018-09-28
DOI:
EISSN:
1465-993X
ISSN:
1465-9921
Pubs id:
pubs:945763
URN:
uri:53727dc3-4978-441d-9ec3-4b0a150f3ce9
UUID:
uuid:53727dc3-4978-441d-9ec3-4b0a150f3ce9
Local pid:
pubs:945763

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP