Journal article
A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A
- Abstract:
- Nine modified nucleosides, incorporating zinc-binding pharmacophores, have been synthesised and evaluated as inhibitors of the DNA repair nuclease SNM1A. The series included oxyamides, hydroxamic acids, hydroxamates, a hydrazide, a squarate ester and a squaramide. A hydroxamic acid-derived nucleoside inhibited the enzyme, offering a novel approach for potential therapeutic development through the use of rationally designed nucleoside derived inhibitors.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.1MB, Terms of use)
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- Publisher copy:
- 10.1039/c9ob01133a
Authors
Funding
Bibliographic Details
- Publisher:
- Royal Society of Chemistry
- Journal:
- Organic and Biomolecular Chemistry More from this journal
- Volume:
- 17
- Pages:
- 8094-8105
- Publication date:
- 2019-08-05
- Acceptance date:
- 2019-06-12
- DOI:
- EISSN:
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1477-0539
- ISSN:
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1477-0520
- Pmid:
-
31380542
Item Description
- Language:
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English
- Pubs id:
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pubs:1040002
- UUID:
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uuid:53640059-5608-493f-93f3-da2c6b7b2cc5
- Local pid:
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pubs:1040002
- Source identifiers:
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1040002
- Deposit date:
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2019-08-16
Terms of use
- Copyright holder:
- The Royal Society of Chemistry
- Copyright date:
- 2019
- Notes:
- © The Royal Society of Chemistry 2019. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
- Licence:
- CC Attribution (CC BY)
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