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Journal article

Impaired IFN-gamma-secreting capacity in mycobacterial antigen-specific CD4 T cells during chronic HIV-1 infection despite long-term HAART.

Abstract:

OBJECTIVE: To determine whether long-term HAART in chronic HIV-1 infection restores fully functional Mycobacterium tuberculosis (MTB)-specific CD4 T-cell responses. DESIGN: A cross-sectional study of HIV-1-seropositive subjects on continuous HAART for over one year with CD4 cell counts greater than 300 cells/microl and undetectable viraemia, antiretroviral-naive individuals with primary HIV-1 infection (PHI), and healthy bacillus Calmette-Guérin-vaccinated low-risk controls. METHODS: Purified...

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Publication status:
Published

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Authors


Sutherland, R More by this author
Scriba, TJ More by this author
Ondondo, B More by this author
Robinson, N More by this author
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Journal:
AIDS (London, England)
Volume:
20
Issue:
6
Pages:
821-829
Publication date:
2006-04-05
DOI:
EISSN:
1473-5571
ISSN:
0269-9370
URN:
uuid:5361d6de-f53b-489a-ab46-7f7800342b7d
Source identifiers:
30573
Local pid:
pubs:30573

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