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Heterologous two-dose vaccination with simian adenovirus and poxvirus vectors elicits long-lasting cellular immunity to influenza virus A in healthy adults

Abstract:
Background T-cell responses against highly conserved influenza antigens have been previously associated with protection. However, these immune responses are poorly maintained following recovery from influenza infection and are not boosted by inactivated influenza vaccines. We have previously demonstrated the safety and immunogenicity of two viral vectored vaccines, modified vaccinia virus Ankara (MVA) and the chimpanzee adenovirus ChAdOx1 expressing conserved influenza virus ... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.ebiom.2018.02.011

Authors


Coughlan, L More by this author
Sridhar, S More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Jenner Institute
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Jenner Institute
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Publisher:
Elsevier Publisher's website
Journal:
EBioMedicine Journal website
Volume:
29
Pages:
146-154
Publication date:
2018-02-15
Acceptance date:
2018-02-13
DOI:
ISSN:
2352-3964
Pubs id:
pubs:825876
URN:
uri:5360e7ba-ace2-4886-b57b-f8e8acb45025
UUID:
uuid:5360e7ba-ace2-4886-b57b-f8e8acb45025
Local pid:
pubs:825876

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