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Expression of D-serine and glycine transporters in the prefrontal cortex and cerebellum in schizophrenia.

Abstract:

The NMDA receptor co-agonists D-serine and glycine are thought to contribute to glutamatergic dysfunction in schizophrenia. They are removed from the synapse by specific neuronal and glial transporters, the status of which is clearly relevant to theories of D-serine and glycine function in the disorder. D-serine is primarily transported by Asc-1, and glycine by GlyT1 but maybe also by SNAT2. As a first step to addressing this issue, we studied Asc-1, GlyT1 and SNAT2 expression in dorsolateral...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Hutchinson, L More by this author
von Hesling, M More by this author
Gilbert, EJ More by this author
Brandon, NJ More by this author
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Journal:
Schizophrenia research
Volume:
102
Issue:
1-3
Pages:
283-294
Publication date:
2008-07-05
DOI:
EISSN:
1573-2509
ISSN:
0920-9964
URN:
uuid:5360a66f-a316-4773-ac04-f7dc7a84eb84
Source identifiers:
98072
Local pid:
pubs:98072

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