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Journal article

Signatures of adaptive evolution within human non-coding sequence.

Abstract:

The human genome is often portrayed as consisting of three sequence types, each distinguished by their mode of evolution. Purifying selection is estimated to act on 2.5-5.0% of the genome, whereas virtually all remaining sequence is considered to have evolved neutrally and to be devoid of functionality. The third mode of evolution, positive selection of advantageous changes, is considered rare. Such instances have been inferred only for a handful of sites, and these lie almost exclusively wit...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/ddl182

Authors


Journal:
Human molecular genetics
Volume:
15 Spec No 2
Issue:
SUPPL. 2
Pages:
R170-R175
Publication date:
2006-10-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:531a6d84-7125-48fd-85e3-a5f38a492b41
Source identifiers:
68187
Local pid:
pubs:68187

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