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Front-cell-specific expression of membrane-type 1 matrix metalloproteinase and gelatinase A during cohort migration of colon carcinoma cells induced by hepatocyte growth factor/scatter factor.

Abstract:

Migration of tumor cells is usually assessed as single cell locomotion in vitro using Boyden chamber type assays. In vivo, however, carcinoma cells frequently invade the surrounding tissue as coherent clusters or nests of cells. We have called this type of movement "cohort migration" and developed a two-dimensional in vitro cohort migration model, in which human rectal well-differentiated adenocarcinoma cells (L-10) migrate from piled-up cell islands as coherent sheets of cells when stimulate...

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Publication status:
Published

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Authors


Nabeshima, K More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Journal:
Cancer research
Volume:
60
Issue:
13
Pages:
3364-3369
Publication date:
2000-07-05
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:530a6547-f329-4f89-affc-b81c8b2fd39a
Source identifiers:
224471
Local pid:
pubs:224471

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