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The pharmacogenetics of NAT: structural aspects.

Abstract:

Arylamine N-acetyltransferases (NATs) catalyze the transfer of an acetyl group from acetyl-CoA to arylhydrazines and to arylamine drugs and carcinogens or to their N-hydroxylated metabolites. NAT plays an important role in detoxification and metabolic activation of xenobiotics and was first identified as the enzyme responsible for inactivation of the antitubercular drug isoniazid, an arylhydrazine. The rate of inactivation was polymorphically distributed in the population: the first example o...

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Publication status:
Published

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Publisher copy:
10.1517/14622416.3.1.19

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry, BHF Centre of Research Excellence
Mushtaq, A More by this author
Journal:
Pharmacogenomics
Volume:
3
Issue:
1
Pages:
19-30
Publication date:
2002-01-05
DOI:
EISSN:
1744-8042
ISSN:
1462-2416
URN:
uuid:53085d2b-8b78-4cb4-99da-53edecf36a4c
Source identifiers:
259709
Local pid:
pubs:259709

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