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Journal article

Activation of AP-1-dependent transcription by a truncated translation initiation factor.

Abstract:

Int6/eIF3e is a highly conserved subunit of eukaryotic translation initiation factor 3 (eIF3) that has also been reported to interact with subunits of the proteasome and the COP9 signalosome. Overexpression of full-length Int6 or a 13-kDa C-terminal fragment, Int6CT, in the fission yeast Schizosaccharomyces pombe causes multidrug resistance that requires the otherwise inessential AP-1 transcription factor Pap1. Here we show for the first time that Int6CT acts to increase the transcriptional a...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Journal:
Eukaryotic cell
Volume:
4
Issue:
11
Pages:
1840-1850
Publication date:
2005-11-05
DOI:
EISSN:
1535-9786
ISSN:
1535-9778
URN:
uuid:5305903b-2cdd-4d37-a6a9-4392de0b5342
Source identifiers:
19271
Local pid:
pubs:19271

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