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Outer membrane vesicles from Neisseria gonorrhoeae target PorB to mitochondria and induce apoptosis

Abstract:

Neisseria gonorrhoeae causes the sexually transmitted disease gonorrhoea by evading innate immunity. Colonizing the mucosa of the reproductive tract depends on the bacterial outer membrane porin, PorB, which is essential for ion and nutrient uptake. PorB is also targeted to host mitochondria and regulates apoptosis pathways to promote infections. How PorB traffics from the outer membrane of N. gonorrhoeae to mitochondria and whether it modulates innate immune cells, such as macrophages, remai...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.ppat.1006945

Authors


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ORCID:
0000-0002-6947-5317
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ORCID:
0000-0002-4392-3863
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ORCID:
0000-0001-8797-6038
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ORCID:
0000-0003-3091-7154
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
ORCID:
0000-0001-5334-557X
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Contributors

Role:
Editor
Australian Research Council More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Pathogens Journal website
Volume:
14
Issue:
3
Pages:
e1006945
Publication date:
2018-03-30
Acceptance date:
2018-02-21
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Pubs id:
pubs:896304
URN:
uri:52f6799f-5ed2-4cf0-9ed2-f30ff3350bdf
UUID:
uuid:52f6799f-5ed2-4cf0-9ed2-f30ff3350bdf
Local pid:
pubs:896304

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