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Evaluation of two lead malaria transmission blocking vaccine candidate antibodies in natural parasite-vector combinations

Abstract:

Transmission blocking vaccines (TBV) which aim to control malaria by inhibiting human-to-mosquito transmission show considerable promise though their utility against naturally circulating parasites remains unknown. The efficacy of two lead candidates targeting Pfs25 and Pfs230 antigens to prevent onwards transmission of naturally occurring parasites to a local mosquito strain is assessed using direct membrane feeding assays and murine antibodies in Burkina Faso. The transmission blocking acti...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41598-017-06130-1

Authors


Bompard, A More by this author
Yerbanga, RS More by this author
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Department:
Oxford, MSD, NDM, Jenner Institute
More by this author
Department:
Oxford, MSD, NDM, Jenner Institute
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PATH Malaria Vaccine Initiative More from this funder
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Grant:
MRC/DFID Concordat agreement
Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Issue:
1
Pages:
Article: 6766
Publication date:
2017-07-28
DOI:
ISSN:
2045-2322
Pubs id:
pubs:713297
URN:
uri:52f66667-f8ea-4c23-9dc2-0c6569e2109c
UUID:
uuid:52f66667-f8ea-4c23-9dc2-0c6569e2109c
Local pid:
pubs:713297
Language:
English

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