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The basis of genetic rearrangements in mupirocin resistance plasmids

Abstract:

Staphylococcus aureus is a Gram positive potentially pathogenic bacterium which has a propensity to gather resistance determinants. Mupirocin is a novel topical antibiotic active against many Gram positive species, including staphylococci and effective in the treatment and prevention of staphylococcal infections. Mupirocin acts by competitively inhibiting the charging of isoleucyl tRNA-synthetase (IRS) with isoleucine. Resistance has been observed in Staphylococcus aureus

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Institution:
University of Oxford
Department:
Life and Environmental Sciences Division

Contributors

Role:
Supervisor
Role:
Supervisor
Publication date:
1994
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Barcode:
603840844
URN:
uuid:52f63fc6-72c8-4d53-a9b0-e2081026c4f9
Local pid:
td:603840844

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