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Journal article

Mdm2 widens its repertoire.

Abstract:

The p53 tumor suppressor protein is a DNA damage responsive transcription factor that affects diverse cellular processes which include transcription, DNA synthesis and repair, cell cycle arrest, senescence and apoptosis. The Mdm2 oncoprotein is a primary regulator of p53, mediating p53 control via ubiquitin-dependent proteasomal degradation. During DNA damage, the interaction between p53 and Mdm2 is reduced, which allows p53 levels to accumulate. p53 activity is tightly controlled and regulat...

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Publication status:
Published

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Publisher copy:
10.4161/cc.6.7.4086

Authors


Coutts, AS More by this author
La Thangue, NB More by this author
Journal:
Cell cycle (Georgetown, Tex.)
Volume:
6
Issue:
7
Pages:
827-829
Publication date:
2007-04-05
DOI:
EISSN:
1551-4005
ISSN:
1538-4101
URN:
uuid:52f0e391-067d-4557-89c6-9f2c9112f363
Source identifiers:
256518
Local pid:
pubs:256518

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