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Induction of heterosubtypic cross-protection against influenza by a whole inactivated virus vaccine: The role of viral membrane fusion activity

Abstract:

Background: The inability of seasonal influenza vaccines to effectively protect against infection with antigenically drifted viruses or newly emerging pandemic viruses underlines the need for development of cross-reactive influenza vaccines that induce immunity against a variety of virus subtypes. Therefore, potential cross-protective vaccines, e.g., whole inactivated virus (WIV) vaccine, that can target conserved internal antigens such as the nucleoprotein (NP) and/or matrix protein (M1) nee...

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Authors


Budimir, N More by this author
Huckriede, A More by this author
Meijerhof, T More by this author
Gostick, E More by this author
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Journal:
PLoS ONE
Volume:
7
Issue:
1
Pages:
e30898-e30898
Publication date:
2012-01-27
DOI:
EISSN:
1932-6203
URN:
uuid:52e5b1a1-f60b-463e-89a7-6e61fe423f31
Source identifiers:
480335
Local pid:
pubs:480335
Language:
English

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