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Lineage structure of Streptococcus pneumoniae may be driven by immune selection on the groEL heat-shock protein

Abstract:

Populations of Streptococcus pneumoniae (SP) are typically structured into groups of closely related organisms or lineages, but it is not clear whether they are maintained by selection or neutral processes. Here, we attempt to address this question by applying a machine learning technique to SP whole genomes. Our results indicate that lineages evolved through immune selection on the groEL chaperone protein. The groEL protein is part of the groESL operon and enables a large range of proteins t...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41598-017-08990-z

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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
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Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Pages:
9023
Publication date:
2017-08-22
Acceptance date:
2017-07-11
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Pubs id:
pubs:718278
URN:
uri:52e4b57b-8bfc-43bd-acae-995cc1d5c069
UUID:
uuid:52e4b57b-8bfc-43bd-acae-995cc1d5c069
Local pid:
pubs:718278

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