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A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2.

Abstract:

The snake venom rhodocytin has been reported to bind to integrin alpha2beta1 and glycoprotein (GP) Ibalpha on platelets, but it is also able to induce activation independent of the 2 receptors and of GPVI. Using rhodocytin affinity chromatography, we have identified a novel C-type lectin receptor, CLEC-2, in platelets that confers signaling responses to rhodocytin when expressed in a cell line. CLEC-2 has a single tyrosine residue in a YXXL motif in its cytosolic tail, which undergoes tyrosin...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1182/blood-2005-05-1994

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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British Heart Foundation More from this funder
Wellcome Trust More from this funder
Biotechnology and Biological Sciences Research Council More from this funder
Publisher:
American Society of Hematology Publisher's website
Journal:
Blood Journal website
Volume:
107
Issue:
2
Pages:
542-549
Publication date:
2006-01-15
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:52d33eed-2c60-4350-b218-605037b4b2e9
Source identifiers:
99967
Local pid:
pubs:99967

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