Journal article
A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2.
- Abstract:
-
The snake venom rhodocytin has been reported to bind to integrin alpha2beta1 and glycoprotein (GP) Ibalpha on platelets, but it is also able to induce activation independent of the 2 receptors and of GPVI. Using rhodocytin affinity chromatography, we have identified a novel C-type lectin receptor, CLEC-2, in platelets that confers signaling responses to rhodocytin when expressed in a cell line. CLEC-2 has a single tyrosine residue in a YXXL motif in its cytosolic tail, which undergoes tyrosin...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1182/blood-2005-05-1994
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Authors
Funding
+ Ministry of Education, Culture, Sports, Science and Technology of Japan
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Grant:
16790533
British Heart Foundation
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Wellcome Trust
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Biotechnology and Biological Sciences Research Council
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Bibliographic Details
- Publisher:
- American Society of Hematology Publisher's website
- Journal:
- Blood Journal website
- Volume:
- 107
- Issue:
- 2
- Pages:
- 542-549
- Publication date:
- 2006-01-15
- DOI:
- EISSN:
-
1528-0020
- ISSN:
-
0006-4971
- Source identifiers:
-
99967
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:99967
- UUID:
-
uuid:52d33eed-2c60-4350-b218-605037b4b2e9
- Local pid:
- pubs:99967
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- American Society of Hematology
- Copyright date:
- 2006
- Notes:
- © 2006 by The American Society of Hematology. The final version is available online from The American Society of Hematology at: [10.1182/blood-2005-05-1994]
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